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COMPARING THE EFFECT OF ONDANSETRON AND DEXAMETHASONE AND METOCLOPRAMIDE IN REDUCING POSTOPERATIVE COMPLICATION AFTER SURGERY
ESRA Academy. Isazadehfar K. Sep 8, 2016; 138241; 0059 Topic: PROCEDURE BASED - EVIDENCE BASED RA AND PERIOPERATIVE ANALGESIA
Dr. Khatereh Isazadehfar
Dr. Khatereh Isazadehfar

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Abstract
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Background and Aims:

Nausea, vomiting and pain are common and distressing postoperative complication after both inpatient and day care surgery. The aim of this study was to compare the efficacy of ondansetron and dexamethasone and metoclopramide in reducing complication after surgery


Methods:

In this study, 90 patients undergoing laparoscopic cholecystectomy were randomly allocated into three equal groups (n =30) and in the first group 10 mg metoclopramide, in the second group 4 mg ondansetron and for third group 8mg dexamethasone preoperatively were injected. Shivering in recovery; nausea, vomiting and pain in recovery and 6 hours and 24 hours after surgery were evaluated. Data were analyzed by SPSS with chi-square and analysis of variance (ANOVA). P <0.05 was considered significant

Results:

The incidence of vomiting, shivering and pain during recovery was not significant between three groups. (p >0.05). The incidence of nausea in recovery in ondansetron was lower than two other groups (p 0.023), whereas there was not any significant difference between other groups (p=1). The incidence of vomiting and nausea after 6 hr. was not significant between groups. (p >0.05), whereas pain after 6 hr. was statistically significant between groups (p=0.01). The incidence of vomiting and pain after 24 hr. in spite of nausea (p=0.045) was not significant between groups. (p >0.05)

Conclusions:

For prevention of vomiting after laparoscopic cholecystectomy, all drugs are effective. In comparing these drugs, in preventing of nausea in recovery ondansetron is more effective than the others, whereas there was not any significant difference between drugs 6 and 24 hr. after surgery

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