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EFFECTS OF SEDATION ON SPINAL ANESTHESIA-INDUCED MATERNAL HYPOTENSION IN PREOPERATIVELY ANXIOUS PARTURIENTS UNDERWENT URGENT CATEGORY-1 CESAREAN SECTION: A HISTORICAL COHORT STUDY
ESRA Academy. Salviz E. Sep 8, 2016; 138245; 0063 Topic: Obstetric Population
Dr. Emine Aysu Salviz
Dr. Emine Aysu Salviz

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Abstract
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Background and Aims:

This study was designed to investigate the effect of sedation on maternal hypotension in preoperatively anxious parturients underwent urgent category-1 Cesarean section (C/S) under spinal anesthesia (SA).

Methods:

After institutional ethics committee approval, parturients with high preoperative anxiety scores (VAS-A≥70) underwent category-1 C/S under SA with thiopental 2mg/kg (if needed additional 50 mg) sedation until reaching Ramsay sedation score≥3 (Group S, n=49), and without any other type of sedation (Group NS, n=53) were included in the analysis. Hemodynamic parameters and maximum systolic arterial pressure (SAP) reductions (%) from the baseline following SA were recorded. Maternal hypotension (SAP≥30% decrease from baseline or <100 mmHg) and bradycardia (HR<55 beats/min) incidences, required ephedrine (if needed, 5mg IV bolus) and atropine (if needed 0.5mg IV bolus) doses, and newborn Apgar scores were recorded.

Results:

Fifty-nine parturients’ data, 29 in Group S and 30 in Group NS were used for the analysis. The maximum SAP reductions from the baseline were 23±12.8% and 30.8±16.1% in Group S and Group NS, respectively (P=0,044, Figure 1). Incidences of hypotension and bradycardia, required ephedrine and atropine doses, and newborn Apgar scores at 1st and 5th min were shown in Table 1.

Conclusions:

The maximum SAP reduction, hypotension incidence and required doses were lower in thiopental sedation used preoperatively anxious parturients who underwent category-1 C/S under SA.

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