ESRA Academy. Tuncer Peker T. Sep 8, 2016; 138292; 0116 Topic: Obstetric Population
Assoc. Prof. Tulay Tuncer Peker
Assoc. Prof. Tulay Tuncer Peker

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Background and Aims:

We aimed to compare the maternal and fetal effects of two different concentrations of bupivacaine combined with fentanyl for patient controlled epidural analgesia (PCEA) during labor. 


Following instutional ethical committee approval, sixty ASA I-II primiparous women were randomly allocated into 4 groups. Parturients in groups I-II received an initial dose of 10 ml bupivacaine 0.0625% and fentanyl 25 mcg. For PCEA, bupivacaine 0.0625%-fentanyl 2 mcg/ml solution was used as 2 ml bolus with 10 min lock-out interval in group I, and 4 ml bolus with 20 min interval in group II. Parturients in groups III-IV received an initial dose of 10 ml bupivacaine 0.125% and fentanyl 25 mcg. For PCEA, bupivacaine 0.125%- fentanyl 2 mcg/ml solution was used as 2 ml bolus with 10 min lock-out interval in group III, and 4 ml bolus with 20 min interval in group IV. VAS levels, number of received bolus doses, duration of labor, Apgar scores, maternal and obstetrician's satisfaction scores were recorded. 


In groups III-IV VAS levels were lower than groups I-II during labor and at delivery. Number of received PCEA bolus doses were higher in groups I-II compared to groups III-IV. Duration of labor, and Apgar scores showed no difference between groups. Maternal and obstetrician’s satisfaction scores were higher in groups III-IV compared to groups I-II. 


Bupivacaine 0.125%-fentanyl 2mcg/ml combination offered better analgesia compared to bupivacaine 0.0625%-fentanyl 2mcg/ml for PCEA during labor. The analgesic efficacy did not change when the same concentrations were delivered with different bolus doses and lockout periods.

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