ESRA Academy. Ifrim D. Sep 8, 2016; 138297; 0123 Topic: Acute Postoperative Pain - Postoperative & Perioperative Analgesia
Dr. Dragos Ifrim
Dr. Dragos Ifrim

Access to Premium content is currently a membership benefit.

Click here to join ESRA or renew your membership.

Discussion Forum (0)
Rate & Comment (0)
Background and Aims:

Histamine-H1 receptor antagonists have been involved in the inhibition of the NMDA receptor. Therefore we measured the postoperative hyperalgesia after administration of hydroxyzine.


During this prospective double-blinded randomized pilot study, approved by the Ethical Committee, 36 patients scheduled for total hip arthroplasty received orally, either hydroxyzine 150 mg (GH) or placebo (GP) before surgery. Anaesthesia was conducted under sevoflurane (MAC= 2%) and boluses of sufentanil. Consumption of sufentanil was recorded. Pain scores (0-10), morphine consumption (mg) and area of hyperalgesia (cm2), evaluated with Von Frey filaments, were recorded postoperatively during 24 hours. Student t-test and continuous mixed models were performed.


Groups were similar in terms of demographic data, duration of anaesthesia and surgery (P> 0.05). Peroperative requirement of sufentanil was similar in GP and GH (20 µg [15–22.25] vs 22.5 µg [20-25] ; P= 0.0577). Morphine consumption increased similarly in both groups (5.56 ± 3.71 mg up to 14.11 ± 5.71 mg in GP vs 4.89 ± 3.85 mg up to 13.11 ± 5.94 mg in GH ; P= 0.512). Pain decreased from 5.17 ± 1.91 to 0.83 ± 1.04 in GP and from 5.28 ± 1.81 to 1.39 ± 1.29 in GH: there was no difference between groups (P= 0.508). The area of hyperalgesia was similar between groups: 90.87 cm2 [46.27 – 108.37] in GP vs 54.61 cm2 [44.34 – 107.74] in GH; P= 0.719.


Under the condition of the study, hydroxyzine is devoid of antihyperalgesic effects in total hip arthroplasty during the early postoperative period.

Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.

Save Settings