ESRA Academy. Urias E. Sep 8, 2016; 138349; 0185 Topic: Preoperative Considerations/ Safety /Complications
Dr. Emma Urias
Dr. Emma Urias

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Background and Aims:

The use of beta blockers protects patients with ischemic heart disease. The extension of this concept to perioperative patients initially seen that has produced promising results, with reductions in perioperative myocardial ischemia and long-term cardiovascular complications observed in several small randomized trials. However, larger, or not later trials have shown no benefit or increased morbidity encountered (particularly stroke), despite the reduction of cardiovascular events.

Objetive:Hemodynamic changes assess the use of metoprolol in the perioperative period in patients who are undergoing laparoscopic cholecystectomy.


It is a controlled clinical trial randomized double-blind using metoprolol versus placebo in patients who underwent laparoscopic cholecystectomy, were included patients scheduled for laparoscopic cholecystectomy, without contraindications to the use of metoprolol. Patients undergoing treatment with metoprolol were excluded.


84 patients were included, two groups, 42 patients in each. Group 1: Control (placebo) and Group 2: Experimental (Metoprolol 100mg Oral c/ 24 h). It was found that heart rate in 23 (54.8%) of Group 1 and 3 (7.1%) Group 2 showing statistical significance (p=.000), however there was no significance for hemodynamic instability. (Figure 1) In demographic variables such as sex, age, there were no differences in the study.


None of the patients in our study presented data from ischemic heart disease or atrial fibrillation. We must consider that patients enrolled in our study did not have high cardiovascular risk. In transanesthesic 3 patients presented isolated ventricular premature complexes, 1 patient in the metoprolol group and 2 patients in the placebo group.

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