ESRA Academy. Nasseri K. Sep 8, 2016; 138365; 0203 Topic: Adjuvant Drugs
Dr. Karim Nasseri
Dr. Karim Nasseri

Access to Premium content is currently a membership benefit.

Click here to join ESRA or renew your membership.

Discussion Forum (0)
Rate & Comment (0)
Background and Aims:

Short duration of single shot spinal solutions, along with advantages of protensive postoperative analgesia, eventuate to add adjutant to them. The aim of present study was to assess the postoperative analgesic effects of intrathecal dexmedetomidine in addition to bupivacaine in parturient undergoing non-emergent caesarean section.


In these double-blind randomized trial, a total of fifty ASA I or II parturient, scheduled for non-emergent caesarean section, were randomly allocated in two equal groups to receive either intrathecal 0.5% hyperbaric Bupivacaine (12.5 mg) (group B) alone, or with 5 microgram dexmedetomidine (group D).All patients received 100mg suppository diclofenac in recovery room and 12h later. In case of visual analog scale (VAS) ≥ 4 an additional analgesic escape dose were administered intravenously (2.5 mg morphine). The onset time of post-operative pain, VAS in 12, and 24 h after operation, and amount of i.v. morphine during the first 24h postoperative were noted and compared across two groups.


Duration of analgesia was significantly longer in group D (326±34 min) as compared to group B (197 ±26 min). The mean VAS was 2.9±1.3 in group D and 4.8±1.6 in group B in first 12h (p= 0.01), and 3.9±1.1 in compare to 3.7±1.2 in group D and B respectively after 24h (p=0.976). The mean dose of rescue analgesic within 24h in group D was significantly lesser than those of group B (P < 0.05).


Addition of dexmedetomidine to intrathecal bupivacaine in cesarean section, results in better post-operative analgesia without having significant impact on incidence of side effects.

Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.

Save Settings