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A RANDOMIZED-CONTROLLED, DOUBLE-BLIND STUDY TO EVALUATE EFFICACY OF INTRATHECAL DEXMEDETOMIDINE ON POSTOPERATIVE ANALGESIA IN CESAREAN SECTION
ESRA Academy. Nasseri K. Sep 8, 2016; 138365
Topic: Adjuvant Drugs
Dr. Karim Nasseri
Dr. Karim Nasseri

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Abstract
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Background and Aims:

Short duration of single shot spinal solutions, along with advantages of protensive postoperative analgesia, eventuate to add adjutant to them. The aim of present study was to assess the postoperative analgesic effects of intrathecal dexmedetomidine in addition to bupivacaine in parturient undergoing non-emergent caesarean section.

Methods:

In these double-blind randomized trial, a total of fifty ASA I or II parturient, scheduled for non-emergent caesarean section, were randomly allocated in two equal groups to receive either intrathecal 0.5% hyperbaric Bupivacaine (12.5 mg) (group B) alone, or with 5 microgram dexmedetomidine (group D).All patients received 100mg suppository diclofenac in recovery room and 12h later. In case of visual analog scale (VAS) ≥ 4 an additional analgesic escape dose were administered intravenously (2.5 mg morphine). The onset time of post-operative pain, VAS in 12, and 24 h after operation, and amount of i.v. morphine during the first 24h postoperative were noted and compared across two groups.

Results:

Duration of analgesia was significantly longer in group D (326±34 min) as compared to group B (197 ±26 min). The mean VAS was 2.9±1.3 in group D and 4.8±1.6 in group B in first 12h (p= 0.01), and 3.9±1.1 in compare to 3.7±1.2 in group D and B respectively after 24h (p=0.976). The mean dose of rescue analgesic within 24h in group D was significantly lesser than those of group B (P < 0.05).

Conclusions:

Addition of dexmedetomidine to intrathecal bupivacaine in cesarean section, results in better post-operative analgesia without having significant impact on incidence of side effects.

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