Save
ADDITION OF LIPOSOME BUPIVACAINE (EXPAREL®) TO BUPIVACAINE HYDROCHLORIDE RESULTS IN SIMILAR BLOCK ONSET CHARACTERISTICS BUT SIGNIFICANTLY LONGER ANALGESIA IN PATIENTS WITH MAJOR SHOULDER SURGERY
ESRA Academy. Leunen I. Sep 8, 2016; 138392; 0234 Topic: Local Anaesthetics
Dr. Ine Leunen
Dr. Ine Leunen

Access to Premium content is currently a membership benefit.


Click here to join ESRA or renew your membership.

Abstract
Discussion Forum (0)
Rate & Comment (0)
Background and Aims:

The brachial plexus block is an effective analgesic modality for patients having major shoulder surgery. We examined the efficacy of liposome bupivacaine (Exparel®), a novel delayed formulation of bupivacaine HCl, in prolonging postoperative analgesia in patients having interscalene brachial plexus block (ISBPB) for major shoulder surgery.

Methods:

Following IRB approval, fifty adult patients were randomized to receive either 10 mL of liposome bupivacaine 133 mg + 5 mL bupivacaine HCl 0.25% or 15 mL of bupivacaine HCl 0.25% alone. Block onset, pain, postoperative opioid consumption, Overall Benefit of Anesthesia (OBAS) scores, sensory-motor function, grip strength, and side effects were measured through the first postoperative week.

Results:

Worst pain on postoperative days (POD) 1-3 was significantly lower in patients given liposome bupivacaine + bupivacaine HCl than in patients given bupivacaine HCl alone. Table 1. Onset and subsequent return of sensory and motor function were less steep, though similar, for patients given liposome bupivacaine + bupivacaine HCl than for patients given bupivacaine HCl alone, Figure 1. There were no differences in grip strength, postoperative opioid consumption or in the frequency of side effects reported. OBAS scores were consistently higher in the liposome bupivacaine group throughout the first postoperative week.

Conclusions:

The addition of 10 mL of liposome bupivacaine 133 mg to 5 mL bupivacaine HCl 0.25% significantly prolonged analgesia and patient satisfaction following major shoulder surgery without altering block onset characteristics or increasing sensory-motor profiles, and without increasing the occurrence of side effects when compared to bupivacaine HCl alone.

Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings