ESRA Academy. Valters D. Sep 8, 2016; 138399; 0242 Topic: PHARMACOLOGY OF DRUGS USED IN RA AND PAIN THERAPY
Deniss Valters
Deniss Valters

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Background and Aims:

Selective COX2 inhibitor (Etoricoxib) inhibits the COX2 which results in decreased stimulation of nociceptors and reduced sense of pain.

Aim of study was to compare the efficacy of Etoricoxib in the treatment of postoperative pain after total hip replacement (THR) depending on two timings of administration. 


Prospective randomized study included adult patients undergoing primary THR surgery. Group I (AP) received Etoricoxib 90 mg 2 hours before surgery, the group II (PA) received Etoricoxib 90 mg 1 hour after surgery. The intensity of pain was assessed at rest and on walking as other markers we assessed rescue analgesic morphine, quality of sleep and patient satisfaction with pain relief.


Study included 50 patients in each group 25 patients. Pain at rest and walking was significantly better in AP group. Total received morphine in mg:  AP 13.6  ± 8.79, PA 20.96 ± 11.27. Satisfaction with pain relief was better in AP group.


Selective COX-2 inhibitor Etoricoxib administered before surgery significantly reduced postoperative pain and morphine consumption.

Patients are more satisfied with pain relief receiving Etoricoxib before surgery.


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