ESRA Academy. Mekel-Bobrov N. Sep 8, 2016; 138406; 0250 Topic: NEUROPATHIC PAIN
Disclosure(s): Dr. Nitzan Mekel-Bobrov is a full time employee of Boston Scientific.
Dr. NItzan Mekel-Bobrov
Dr. NItzan Mekel-Bobrov

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Background and Aims:

Anatomically-guided neural targeting, known as Neural Targeting SCS, is a recently introduced paradigm consisting of a software algorithm that computationally derives 3-dimensional field potentials coupled with current fractionalization technology to customize neurostimulation with precise specificity. We therefore hypothesized this new modality would foster long term robust low-back pain relief.


LUMINA is a retrospective, multi-center, consecutive, observational, real-world study across 13 clinical sites of 213 patients treated out to 2 years post-implant using the Precision Spectra SCS system (Boston Scientific Corporation) . Pain intensity was measured on a 0-10 numerical rating scale – NRS. Responder Rates (≥ 50% pain reduction) out to 2 years were calculated. Responder rates using a previous generation system (non-Neural Targeting SCS) versus a Neural Targeting SCS system were determined.


The mean overall pain reduction in all subjects and a subset of subjects classified as “severe” (NRS >8.0) decreased 4.2 and 5.3 points from baseline (7.17 and 8.75), respectively.  All subjects (and 'severe' subset) reporting low back pain only displayed a decrease in mean low back pain of 4.1 and 5.6 points from baseline (7.21 and 8.60), respectively. Responder rates were greater than 70% for overall and low back pain. Compared to a previous generation SCS system, statistically significant increases in response rates were observed using Neural Targeting SCS.


Neural Targeting SCS is a novel SCS variant based on anatomical placement of stimulation using a unique software algorithm. Using this paradigm, this study demonstrated long-term evidence of overall and low-back pain relief out to 2 years.

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