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IMPACT OF NEURAL EXPOSURE TO LOCAL ANAESTHETIC ON NERVE BLOCK DURATION: A COHORT STUDY IN HEALTHY VOLUNTEERS
Author(s): ,
Herold Madsen, M.*
Affiliations:
Nordsjællands Hospital - Hillerød, Anaesthesiology and Intensive Care, Hillerød, Denmark
,
Behrend Christiansen, C.
Affiliations:
Nordsjællands Hospital - Hillerød, Anaesthesiology and Intensive Care, Hillerød, Denmark
,
Hyldborg Lundstrøm, L.
Affiliations:
Nordsjællands Hospital - Hillerød, Anaesthesiology and Intensive Care, Hillerød, Denmark
Henrik Wiborg Lange, K.
Affiliations:
Nordsjællands Hospital - Hillerød, Anaesthesiology and Intensive Care, Hillerød, Denmark
ESRA Academy. Herold Madsen M. Sep 13, 2017; 196109
Mikkel Herold Madsen
Mikkel Herold Madsen
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Abstract
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Background and Aims:

Effects of circumferential spread on a nerve block is well described1,2. Longitudinal local anaesthetic (LA) spread however, has not been investigated. One study showed decrements in action potentials when exposure length to LA was incrementally increased in a frog model3

We investigated whether longitudinal neural exposure to LA influences nerve block duration.

Methods:

We analysed data from an ethical board approved prospective consecutive cohort of 120 healthy volunteers with a catheter-based common peroneal nerve block (3-20 mL of ropivacaine 0.2%).

Neural exposure to LA in millimetres was evaluated by ultrasonography by two observers. Parameters related to the intervention and the volunteers were registered and retrieved for assessment (Table 1). Sensory block duration defined as insensitivity towards cold was evaluated blinded to all other covariates.

We performed univariate and multivariate linear regression analyses to explore a potential association between neural exposure and block duration.

Results:

All 120 volunteers had sensory nerve block. Duration ranged from 2 – 29 hours.

We found a univariate significant positive association between longitudinal neural exposure to LA and block duration (P < 0.0002). However, in our multivariate regression model neural exposure was excluded (P = 0.086). Volume of LA (volume: P < 0.0001), gender (P = 0.001) and BMI (P = 0.001) remained significantly associated with block duration.

Conclusions:

Longitudinal neural exposure to LA was not associated with nerve block duration.

Volume of LA, gender and BMI were significantly associated with nerve block duration.

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